Selected Publications


Gao  D, Joshi N, Choi H, Ryu S, Hahn M, Catena R, Sadik H, Argani P, Wagner P, Vahdat LT, Port J, Stiles B, Sukumar S, Altorki NK, RafiiS. and Vivek Mittal (2012). Myeloid progenitor cells in premetastatic lungs promote metastases by inducing mesenchymal to epithelial transition  (in press)

Bhuvanesh D, Tan N,  Mittal V and Chang J. (2011) Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Research, in press)

Jain S et al. (2011).  Incremental increase in VEGFR1(+) hematopoietic progenitor cells and VEGFR2(+) endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients. Breast Cancer Res Treat.  Dec 9. [Epub ahead of print]

Ryu S,  Joshi N,  McDonnell K, Woo J,  Choi H, Gao D, McCombie W  and  Mittal V (2011) Discovery of novel human breast cancer microRNAs from deep sequencing data by analysis of pri-microRNA secondary structures. PLoS one, 6(2): e16403.

BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, Rafii S. (2010) Inductive angiocrine signals from sinusoidal endothelium are required for liver generation. Nature. 2010 Nov 11;468(7321):310-5.

Mellick. A.S., Plummer, P.N., Nolan, D.J., Gao, D., Bambino, K., Hahn, M., Turner, V., McDonnell, K., Benezra, R., Brinks, R., Swarbick, A, and Mittal, V. (2010) Using transcription factor Id1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth. Cancer Research, 70 (18): 7273

Zhan Yao, Silvia Fenoglio, Ding Cheng Gao , Matthew Camiolo , Brendon Stiles, Trine Lindsted, Michaela Schlederer, Chris Johns, Nasser Altorki, Vivek Mittal, Lukas Kenner, Raffaella Sordella (2010)  A TGF-Beta, IL-6 Axis Mediates Selective And Adaptive Mechanisms Of Resistance To Molecular Targeted Therapy In Lung Cancer. Proceedings of the National Academy of Sciences USA, 107:15535 

Penack O, Henke E, Suh D, King CG, Smith OM, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C,  Murphy GF, Lu TT, May C, Scheinberg DA,Gao DC, Mittal V, Heller G, Benezra R, van den Brink MR. (2010) Inhibition of neovascularization to simultaneously ameliorategrowth. J Natl Cancer Inst. 102(12):894-908. 

McGraw, T and Mittal, V  (2010) Metabolism regulates cell differentiation. Nature Chemical Biology, (3):176-177.

Gao D and Mittal V (2009) The role of bone marrow-derived cells in tumor growth, metastasis initiation and progression. Trends in Molecular Medicine, 43, 259-63

Gao D, Nolan DJ, McDonnell K, Vahdat L,   Benezra R, Altorki N and Mittal V (2009) Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression. Biochimica et Biophysica Acta, special issue Cancer Reviews,  1796(1), 33-40

Hooper AT, Butler JM, Nolan DJ, Kranz A, Iida K, Kobayashi M, Kopp HK, Shido K, Petit I, Yanger K, Dylon, J , Wu Y, Witte L, Zhu Z, Pytowski B, Rosenwaks Z, Mittal V, Sato T, Rafii S. (2009) Engraftment and –mediated regeneration of sinusoidal endothelial cells.
Cell Stem Cell 4, 187-8 

Kerbel RS, Benezra R, Lyden DC, Hattori K, Heissig B, Nolan DJ, Mittal V, Shaked Y, Dias S, Bertolini F, Rafii S. Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas. Proceedings of the National Academy of Sciences USA, 2008 Aug 26;105(34):E54

Gao, D., Nolan, D.J., Mellick. A.S., Bambino, K., McDonnell, K. and Mittal, V. (2008) Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science, 319, 195-8. 

Perspectives by S. Rafii and D. Lyden Science, 319, 163-5 

Ciarrocchi, A., Jankovic, V., Shaked, Y., Nolan, D.J., Mittal, V., Kerbel, R.S., Nimer, S.D. and Benezra, R (2007) Id1 restrains p21 expression to control endothelial progenitor cell formation. Plos One,2 (12):e1338

Nolan, D.J., Ciarrocchi, A., Mellick, A.S., Jaggi, J.S., Bambino, K., Gupta, S., Heikamp, E., McDevitt, M.R., Scheinberg, D.A., Benezra, R. and Mittal, V. (2007) Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes and Development, 21, 1546-1558.

Mittal, V. and Nolan, D.J. (2007) Genomics and Proteomics approaches in Tumor Angiogenesis Research. Expert Review of Molecular Diagnostics. 7: 133-47

Rubin, C.T., Capilla, E., Luu, Y.K., Busa, B., Crawford, H., Nolan, D.J., Mittal, V., Rosen, C., Pessin, J.E.  and Judex, S. (2007) Adipogenesis is inhibited by brief, daily exposure to high frequency, extremely Low magnitude mechanical signals. Proceedings of the National Academy of Sciences USA, 104:17879

Gupta, G.P., Perk, J., Acharyya, S., Candia, P.D., Mittal, V., Todorova-Manova, K., Gerald, W.L.,   Brogi, E., Benezra, R. and Massagué J. (2007)   Id genes mediate tumor re-initiation during breast cancer lung metastasis. Proceedings of the National Academy of Sciences USA, 104:19506

Jaggi, J.S., Henke, E., Seshan, S.V., Kappel, B.J., Chattopadhyay, D., May, C., McDevitt. M., Nolan, D., Mittal, V., Benezra, R. and Scheinberg, D. A. (2007) Selective alpha-particle depletion of tumor vasculature with vessel normalization. PLoS one, Issue 3, e267

Benezra, R., Henke, E., Ciarrocchi. A., Ruzinova. M., Solit, D., Rosen, N., Nolan, D, Mittal, V. and de Candia. P. (2005) Induction of complete regressions of oncogene-induced breast tumors in mice. Cold Spring Harbor Symp. Quant Biol. 70:375-81 

Mittal, V. (2004) Improving the efficiency of RNA interference in mammals. Nature Reviews Genetics. 5:355-365  

Lippman, Z., Gendrel, A.V., Black, M., Vaughn, M.W., Dedhia, N., McCombie, W.R., Lavine, K., Mittal, V., May, B.,. Kasschau, K.D., Carrington, J.C., Doerge, R.W., Colot, V., and Martienssen, R (2004) Role of transposable elements in heterochromatin and epigenetic control. Nature. 430: 471-476  

Hernando, E., Nahle, Z., Juan, G, Alaminos, M., Diaz-Rodriguez, E., Hemann, M., Michel, L., Mittal, V., Benezra. R, Gerald, W., Lowe, S.W. and Cordon-Cardo, C (2004) Rb inactivation uncouples cell cycle progression from mitotic control producing genomic instability. Nature. 430: 797-802 

Gupta, S., Schoer, R. A., Egan, J.E., Hannon, G.J and Mittal, V. (2004) Inducible, reversible and stable RNA interference in mammalian cells. Proceedings of the National Academy of Sciences USA 101:1929-1932 

Kumar, R., Conklin, D. S., and Mittal, V. (2003). High throughput selection of effective RNAi probes for gene silencing. Genome Research. 13:2333-2340 

Ruzinova, M.B., R.A. Schoer, W. Gerald, J.E. Egan, P.P. Pandolfi, S. Rafii, K. Manova, V. Mittal*, and R. Benezra* (2003). Effect of angiogenesis inhibition by Id loss and the contribution of bone marrow derived endothelial precuresor cells in spontaneous murine tumors. Cancer Cell. 4: 277-289. (*co-senior authors)

Hemish, J., Nakaya, N., Mittal, V., and Enikolopov, G. (2003). Nitric oxide activates diverse signaling pathways to regulate gene expression. Journal of Biological Chemistry 10: 1074 

Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G.J., Wigler, M.H. and Mittal, V (2001). Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences USA 98, 13043-13048 

Mittal, V., Beicong , Ma and Hernandez, N. (1999). SNAPc: a core promoter factor with a built-in DNA binding damper that is deactivated by the Oct-1 POU domain. Genes and Development 13, 1807-1821 


Henry, R.W., Mittal, V., Ma, B., Kobayashi, R. and Hernandez, N. (1998) SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. Genes and Development 12, 2664-2672. 

Henry, R.W., Ford. E., Mital. R., Mittal, V. and Hernandez, N. (1998) Crossing the line between RNA polymerases: transcription of human snRNA genes by RNA polymerase II and III. Cold Spring Symposium of Quantitative Biology, LXIII, 111-120. 


Huang, C.C., Faber, P., Persichetti, F., Mittal, V., Vonsattel, J-P., MacDonald, M.E. and Gusella, J.F. (1998) Amyloid formation by mutant Huntingtin: Threshold, progressivity and recruitment of normal poly glutamine proteins. Somatic cell and Molecular Genetics, 24, 217-233. 

Mittal, V. and Hernandez, N. (1997). Role for the non-conserved N-terminal domain of human TBP in U6 snRNA transcription. Science 275, 1136-1140. 

Mittal, V., Cleary, M., Herr, W. and Hernandez, N. (1996). The Oct-1 POU-specific domain can stimulate snRNA gene transcription by stabilizing the basal transcription complex SNAPc. Molecular and Cellular Biology 16, 1955-1965.